Boys with XXY are believed to deficient in Testosterone throughout their lives based recent research literature. For this reason, supplementation of their hormonal deficiency is necessary and important to normalize their neurodevelopmental progression. Early Hormonal Treatment (EHT) fosters improved brain development, motor skills and behavioral issues. There have been no known side effects in more than 16 years which is very encouraging regarding this treatment.
More recent research has investigated the possible benefits of hormonal treatment at other critical periods, including hormonal booster treatment (HBT) between 5 and 8 years of age. HBT has been shown to possibly improve areas of working memory and executive function and reduce anxiety symptoms. Further research is underway to determine the most effective timing and dosage of testosterone replacement in boys with extra X chromosomes.
The following questions and answers address the typical concerns and queries of patients. The link to the scientific articles are provided so you can download them if you wish and take them to your medical provider.